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Tenofovir 300 mg tablet is used to treat chronic HIV infection and hepatitis B virus infection. It is available in different strengths including 150 mg, 200 mg, 250 mg and 300 mg. The usual dose for adults (18 years of age and older weighing at least 35 pounds) is a 300 mg tablet per day. Taking certain hepatitis C medicines, including tenofovir, can increase the amount of tenofovir in your body, causing more side effects.