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Tadalafil, the active ingredient in Tadarise Pro 40 Mg, works by relaxing the smooth muscles in the blood vessels of the penis. This increases blood flow to the penile region when sexually aroused, resulting in a stronger and longer-lasting erection. Unlike sildenafil, tadalafil has a longer duration of action, often referred to as the "weekend pill," as its effects last up to 36 hours.