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Malegra 100 mg works by blocking the enzyme phosphodiesterase type 5 (PDE-5). By inhibiting this enzyme, the medication increases levels of a natural chemical called cGMP, which relaxes the smooth muscles of blood vessels and improves blood circulation in the penis. However, the medicine does not cause an erection automatically—sexual arousal is still necessary for it to be effective. The tablet is usually taken 30 to 60 minutes before sexual activity with a glass of water. The effects typically begin within an hour and may last for approximately 4 to 6 hours, although the duration can vary from person to person.