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Malegra 25 mg belongs to a class of drugs known as PDE5 inhibitors. PDE5 (phosphodiesterase type 5) is an enzyme that breaks down cyclic guanosine monophosphate (cGMP), a molecule that plays a critical role in relaxing the smooth muscles in blood vessels. In response to sexual stimulation, the body releases nitric oxide, which leads to the production of cGMP. In men with ED, PDE5 is often overactive, leading to decreased levels of cGMP and insufficient blood flow to the penis. By inhibiting PDE5, Malegra increases cGMP levels, which allows blood vessels to relax, increasing blood flow to the penis and facilitating the ability to achieve and maintain an erection.