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Malegra FXT should not be combined with nitrate medications (commonly used for heart problems) or certain antidepressants without medical supervision, as dangerous interactions may occur. Men with heart disease, liver or kidney problems, or those on medications affecting blood pressure or serotonin levels, should consult a doctor before use. Common side effects may include headache, flushing, dizziness, nausea, nasal congestion, or mild gastrointestinal discomfort. Serious side effects—such as chest pain, fainting, sudden vision or hearing loss, or an erection lasting more than four hours—require immediate medical attention.