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Sildenafil citrate, the active ingredient in Fildena 150 mg, works by inhibiting the PDE5 enzyme, which regulates the breakdown of cyclic guanosine monophosphate (cGMP). By inhibiting PDE5, cGMP levels increase, leading to relaxation of the smooth muscles in the blood vessels of the penis. This relaxation allows for increased blood flow to the penis when sexual stimulation occurs, helping men achieve and sustain an erection.