@felmue This fixed the issue! Thanks. I found that this was the issue. It was using Wire.begin() instead of Wire.begin(0,26)

I bought both the M5StickC Plus and ENV III Hat from digikey, but I have not been able to get temperature from SHT3X in Arduino IDE. I keep getting Wire.endTransmission() return value of for NACK. How do I fix/debug this or is this HAT broken?

#include <M5Unified.h>
#include <Wire.h>

void setup() {
  M5.begin();
  Serial.begin(115200);
  Wire.begin();
  
}

void loop() {
  // Start I2C Transmission
  Wire.beginTransmission(0x44);
  
  // Send measurement command
  Wire.write(0x2C);
  Wire.write(0x06);
  
  // Stop I2C transmission
  int result = Wire.endTransmission();
  if (result != 0) {
    Serial.println("Failed");
    Serial.println(result);
  }
  delay(5000);
}