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Manforce 50 mg is a PDE5 inhibitor, meaning it works by blocking the enzyme phosphodiesterase type 5 (PDE5). This enzyme is responsible for breaking down cGMP (cyclic guanosine monophosphate), which plays a critical role in relaxing the smooth muscles and dilating the blood vessels in the penis. By inhibiting PDE5, Sildenafil helps increase blood flow to the penis, which makes it easier to achieve an erection when sexually aroused.