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Tadalista 20 mg usually starts working within 30 to 45 minutes after intake and its effects can last up to 36 hours, giving a wide window for sexual activity. Unlike some other ED medications, it can be taken with or without food, providing convenience. It is important to take Tadalista 20 mg exactly as prescribed by a healthcare provider. The usual recommendation is to take it once per day, at least 30 minutes before sexual activity. It should not be taken more than once in 24 hours.